It is due to a defect in a DNA ligase. Tetraploidy 4n , is due to a post zygotic non disjunction in mitosis. The condition is not correlated with maternal age.
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In general, de novo rearrangements carry a greater risk of abnormality than inherited ones.
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But Morgan's discoveries with white- and red-eyed flies led him to reconsider each of these hypotheses.
The Meaning of Sex: Genes and Gender
Centromeres help to keep chromosomes properly aligned during the complex process of cell division. Is it a boy or a girl? Robertsonian translocations involving the same chromosome have a higher incidence of uniparental disomy.
Chromosomes Fact Sheet
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